High Yield USMLE notes

In USMLE exams, we usually get a definite idea after reading a question that these 3 out of 5 are wrong choices and we always stuck with two choices in deciding which one is the correct answer. That's why I have pointed out CLUES in BOLD to identify right choices.

What I would recommend is to go through my sample notes (Please click on word "sample notes") and do few questions from that topics. You will be able to answer most of questions and you will find out yourself the usefulness of these notes.

 

I have written these notes in such a way that we can easily remember and understand high yield concepts & we don't get confuse on the test.



Few Examples:

• Abruptio Placenta: painful bleeding, maternal hypertension or cocaine abuse
• Placenta Previa: painless bleeding, placenta implantation over cervical os

• Rheumatic fever: Type-2 HS (Hyper Sensitivity)      
• Rheumatoid arthritis: Type-3 HS

• Carbomyl phosphate in cytoplasm: pyrimidine synthesis
• Carbomyl phosphate in mitochondria: urea cycle [both are different enzymes with similar name]

• Thiazide Diuretics: used in renal stone (hyper calciurea)
• Loop Diuretics: used in hypercalcemia

• Antibody Dependent Cellular Cytotoxicity (ADCC): IgG + NK cells - use CD 16 molecule (Fc receptor) to identify target cells. (NOT CD 56)
• NK cell mediated Cytotoxicity: CD 56 (No antibody involve. e.g. - lysis of infected RBCs)

• de Quarian thyroiditis: (subacute granulomatous): painful, mild hyperthyroidism
• Subacute Lymphocytic thyroiditis: painless, mild hyperthyroidism

• Berger's disease: hematuria following URTI, IgA deposition in mesangium
• Buerger's disease: (thromboangitis obliterates) - Male smoking cigarettes, involvement of toes 

• Pericentral vein zone (zone 3) in liver contains P450 oxidase enzyme system & is most sensitive to Ischemic injury
• Periportal zone (zone 1) in liver is the most sensitive to toxic injury

• Pemphigus vulgaris: IgG against desmosomes (intracellular atttachment), (+) Nikolsky sign, oral lesion
• Bullous Pemphigoid: IgG against basement membrane, (-) Nikolsky sign

• Cortical necrosis of both kidney sparing medulla - DIC
• Sickle cell anemia - Affect medulla most severly - can cause papillary necrosis

• Hypokalamia - "U" wave on EKG       Hyperkalamia - peaked T wave on EKG

These notes are now available on Android and iOS tablets through free Kindle app.

Please feel free to email me if you have any question.

Good Luck

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